Pilot Translational and Clinical Studies Program

Proposed 2021 Timeline

Overview:

The iTHRIV Pilot Translational and Clinical Studies Program is a core component of the NIH-funded Clinical and Translational Sciences Award (CTSA), the integrated Translational Health Research Institute of Virginia (iTHRIV). iTHRIV is a cross-state collaborative research network comprised of 4 research institutions, the University of Virginia, Virginia Tech, Carilion Clinic and Inova Health with a mission of using data to improve health. 

The goal of the iTHRIV Pilot Studies Program is to support innovative approaches to clinical and translational research to foster collaborative research across the iTHRIV partner institutions.  By providing teams with early-stage pilot funding, iTHRIV aims to provide resources to accelerate discovery, generate preliminary data, and support translational science through partnerships across the Commonwealth of Virginia.

Proposals can include the full range of translation from the laboratory to the clinical area.  Areas of particular interest include:

  • Innovative uses of data science to improve health,

  • Research focused on health disparities,

  • Team science collaborations across two or more iTHRIV partner institutions.

iTHRIV has a total of $200,000 to distribute and the number of projects funded will depend on the quality and funding request amounts.  Projects are required to be completed within one year. 

 

Budget Request Options:

  • Single iTHRIV Institution Investigator: up to $25,000 in direct costs, or

  • Multi-iTHRIV Institution Investigators (Requires a minimum of 2 iTHRIV institutions): up to $50,000 in direct costs

 

2021 Anticipated Request for Proposals Timeline:

June 28th, 2021: Release RFP

 

July 6th, 2021 at 4 pm ET: Zoom information session (link to register will be posted with RFP release)

 

August 30th, 2021 by 5 pm: Application Deadline

October 25th, 2021:  Anticipated award notification date

February 1, 2022: Anticipated project start date

Eligibility:

  • All proposals must involve an interdisciplinary team.Multiple PIs or co-PIs is encouraged.

  • Any faculty member eligible to serve as a PI on external grants and contracts at their iTHRIV institution may serve as the contact PI for an application.

  • Multi-Institution projects must include at least 2 separate iTHRIV institutions (Carilion Clinic, Inova, UVA, VT)

  • All projects involving human subjects or vertebrate animals must provide proper regulatory approvals prior to initiation of the research, but not prior to the submission of the proposal.

 

Proposal:

Teams should submit a single PDF containing the following:

  • Application Coversheet (locatedhere)

  • Abstract (500 words or less)

Please Note:  use non-medical terminology to describe your research project and its potential impact.  This abstract will help our community reviewers better understand the proposal.

  • 5-page project description (includes all of the following categories)

    • Specific Aims

    • Impact

    • Research Plan

    • Description of Team

    • Plan for Community Engagement

    • Timeline

    • Plan for Follow-on funding

  • Resource and Data Sharing Plan

This should include your plans for dissemination of data from your project as well as plans for sharing any other resources including model organisms or genomic data sharing. (1 page limit)

  • NIH formatted budget and budget justification (use templates provided here)

  • NIH-style biosketch for each key personnel

 

Funding and Awards:

Single-institution teams may request up to $25,000 of direct costs only, and multi-institution teams may request up to $50,000 of direct costs. All awards require approval from the National Institutes of Health, and funds must be expended within a single year (anticipated funding dates are approximately Feb, 1, 2022- Jan 31, 2023).

Teams should provide an NIH formatted budget and budget justification at the time of application, if the proposal includes collaboration with an iTHRIV partner institution please include separate budget and budget justifications for each institution. Formal approval by the appropriate grants offices will be requested only for those projects selected for funding. No carry over will be permitted.

 

Evaluation Criteria and Proposal Review:

iTHRIV Pilot Studies applications will receive an administrative review for completeness and eligibility, then all applications will be evaluated by reviewers from all four institutions and a community member. The top proposals will be reviewed and approved for funding by the iTHRIV Leadership Council.

Applications will be evaluated based on the following criteria:

  • Does the project involve an innovative approach to an important clinical problem?

  • Is the project supported by appropriate preliminary data supporting the feasibility of translation to the clinic?

  • Does the project employ a team science approach and include personnel with the required expertise? Priority will be given to multi-site collaborative projects.

  • Is the project likely to lead to follow-on funding and/or translation to clinic?

Frequently Asked Questions:

 

1) What does community engagement mean?

  • Identifying and communicating with stakeholders and end-users of the research process.

 

2) Are indirects allowed to be included in the budget?

  • No

 

3) Are references considered part of the 5-page project description?

  • No, references are separate as are the abstract, resource and data sharing plan, budget, budget justification, and NIH biosketches.

4) Are PI’s or Co-I’s required to have effort on the grant?

  • No, PI effort is discouraged, with this limited funding iTHRIV anticipates the majority of the funding will be needed for supplies, support staff, statistical support, etc.

5) Do proposals require review prior to submission by the grants and contracts office?

  • For UVA budgets (even if it is considered a sub-award)-No, but departmental research administrator review is highly recommended.

  • For all other institutions-follow institution guidelines and policies

  • Consortium agreements are NOT needed

6) If this is a multi-institution project, are separate budgets and budget justifications required?

  • Yes-see question #2 for information regarding indirect rates.

 

7) If this is a multi-institution project, are the budgets required to be split evenly between institutions?

  • No-the budgets should be comparable to the work being done at each site.

 

 

Additional questions?  Please contact the iTHRIV Program Manager, Jennifer Phillips JVP8A@hscmail.mcc.virginia.edu or the iTHRIV Grant Administrator, Kayla Calvo KRC7D@hscmail.mcc.virginia.edu

June 28th, 2021:

RFP Release

August 30th, 2021

5 pm ET

Application Deadline

February 1, 2022:

Anticipated project start

July 6th, 2021

4 pm ET (tentative)

Zoom information session

October 25th, 2021: 

Anticipated award notification date